Edgewise Therapeutics, Inc.· EWTX

🇺🇸 US · MidBroad USNASDAQ

HealthcareBiotechnologyWebsite

Price: $44.71
Day: +16.48%
Mkt Cap: $4.81B
52W Range: $12.30 – $48.40
Volume: 4.18M
Beta: 0.28

D55D FrameworkQuarterly Data

Holdings Analysis

Insider activity, institutional flows, and fund ownership.

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stockoscope.com

Edgewise Therapeutics, Inc.

EWTX|Healthcare|Biotechnology

Current price: $45

Smart Money

Dimension 5 of 5

Insider Activity, Q3 2026

Latest scored quarter, net flow, and top transactions by value

Net dollar flow-$7.9M

Net share flow-200.0K

Purchases0 ($0)

Sales2 ($7.9M)

Top Notable Transactions

Insider

Type

Value

Date

Novo Holdings A/S

Purchase

$10.0M

Mar 30

Flynn James E

Purchase

$10.0M

Mar 30

ORBIMED ADVISORS LLC

Purchase

$7.5M

Apr 3

Institutional Ownership, Q1 2026

Ownership share, position changes, share flow, and top holders

Ownership115.2%

13F share flow+18.8%

Investors holding225

+154 adding-94 reducing

112

New 42Inc 112Red 66Closed 28

Top Institutional Holders

Institution

Value

Change

ORBIMED ADVISORS LLC

$488.8M

+2.5%

RA CAPITAL MANAGEMENT, L.P.

$328.5M

+2.5%

PARADIGM BIOCAPITAL ADVISORS LP

$232.0M

+15.4%

BAKER BROS. ADVISORS LP

$207.1M

+2.5%

ETF & Mutual Fund Activity, Q2 2026

Latest meaningful quarter: fund-by-fund buying / unchanged / selling

Funds reporting85

Total shares held12.7M

Share flow-5.5%

23 buying29 selling

Buying 23Unchanged 33Selling 29

Top Fund Holders

Fund

Weight

Change

Fidelity Rutland Square Trust II

1.9M

0.14%

+1.9M

FIDELITY SELECT PORTFOLIOS

1.1M

1.94%

+216.5K

FIDELITY CONCORD STREET TRUST

700.2K

0.26%

-2.6K

VANGUARD SCOTTSDALE FUNDS

415.4K

0.02%

+13.9K

See the complete picture

The full 5D Framework: Business Quality · Peer Comparison · Valuation · Analyst Sentiment · Smart Money

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Generated August 5, 2026

For educational purposes only. Not financial advice. Data may be delayed or incomplete.

Smart Money Sentiment

EWTX Smart Money Sentiment Score

A weighted 1-5 sentiment score across three smart money signals.

Smart Money

2.9/5

Neutral

Weighted across 3 components

Component Breakdown (3 of 3 available)

Insider Activity

40% weight

-14

Institutional Flow

50% weight

Fund Flow

10% weight

-25

Overall Smart Money sentiment of 2.9/5 (Neutral) based on a weighted combination of 3 components. Insider activity uses a relative-baseline comparison against the stock's own history; institutional flow tracks position momentum and 13F share changes; fund flow measures ETF / mutual-fund buying vs selling. Higher scores indicate stronger bullish sentiment from professional investors.Last updated August 4, 2026.

Insider Trading Activity

Insider trading analysis comparing the latest quarter against the stock's own historical baseline.

Insider Activity for EWTX

Net insider share flow by quarter (C-suite & director purchases minus sales)

Neutral

Routine insider selling in Q3 2026

2 sales totaling $7.9M (200.0K shares)

Share volume is elevated at 2.3x the historical average

Buying seen in 2 of 7 quarters

Notable Recent Transactions, EWTX

Top 8 highest-value recent insider trades

Novo Holdings A/S

Insider

Buy

625,000 shares at $16.00

Mar 30, 2021$10.00M

Flynn James E

Insider

Buy

625,000 shares at $16.00

Mar 30, 2021$10.00M

ORBIMED ADVISORS LLC

Director

Buy

372,578 shares at $20.13

Apr 3, 2025$7.50M

Thompson Peter A.

Director

Buy

372,578 shares at $20.13

Apr 3, 2025$7.50M

Russell Alan J

Director

Sell

130,352 shares at $39.41

Jul 1, 2026$5.14M

ORBIMED ADVISORS LLC

Director

Buy

312,500 shares at $16.00

Mar 30, 2021$5.00M

Thompson Peter A.

Director

Buy

312,500 shares at $16.00

Mar 30, 2021$5.00M

ORBIMED ADVISORS LLC

Director

Buy

484,496 shares at $10.32

Sep 16, 2022$5.00M

Institutional Ownership Analysis

Institutional ownership analysis with position momentum, 13F share flow, and ownership percentage trends.

Institutional Ownership Over Time for EWTX

Total dollar value invested by institutions each quarter

Neutral

Mixed institutional activity in Q1 2026

115.2% institutional ownership

Moderate accumulation: 154 adding vs 94 reducing

13F shares decreased by 2.8%, a notable change

Momentum weakening from prior quarter

Position Changes

Q2 2026: how are institutions adjusting their positions?

+17 growing-198 shrinkingNet: -181

183

New (4)

Increased (13)

Reduced (15)

Closed (183)

Top Institutional Holders, EWTX

Largest 8 institutional positions by ownership percentage as of Q2 2026

ABRDN PLC

647.9K

$26.3M

Ownership

0.60%

-21.6%

PEREGRINE CAPITAL MANAGEMENT LLC

198.6K

$8.1M

Ownership

0.19%

-4.8%

QUANTUM PRIVATE WEALTH, LLC

113.4K

$4.6M

Ownership

0.11%

-2.8%

ALPS ADVISORS INC

108.8K

$4.4M

Ownership

0.10%

+24.6%

MOODY ALDRICH PARTNERS LLC

105.0K

$4.3M

Ownership

0.10%

-8.1%

NEW YORK STATE COMMON RETIREMENT FUND

80.2K

$3.3M

Ownership

0.07%

-9.8%

CITIGROUP INC

59.6K

$2.4M

Ownership

0.06%

+221.7%

KNIGHTS OF COLUMBUS ASSET ADVISORS LLC

38.6K

$1.6M

Ownership

0.04%

+0.6%

ETF and Mutual Fund Holdings

ETF and mutual fund activity breakdown showing buying vs selling funds, top fund holders, and detailed holdings.

Fund Activity

Q2 2026: 85 ETFs and mutual funds reporting

23 buying29 sellingNet: -6

Buying (23)

Unchanged (33)

Selling (29)

Bearish Signal

Funds distributing in Q2 2026

85 ETFs and mutual funds reporting

29 funds selling vs 23 buying

Top Fund Holders, EWTX

Largest 8 ETF and mutual fund positions by shares held as of latest filing

Fidelity Rutland Square Trust II

1.9M

Weight

0.14%

Increased

FIDELITY SELECT PORTFOLIOS

1.1M

Weight

1.94%

Increased

FIDELITY CONCORD STREET TRUST

700.2K

Weight

0.26%

Decreased

VANGUARD SCOTTSDALE FUNDS

415.4K

Weight

0.02%

Increased

SCHWAB STRATEGIC TRUST

399.6K

Weight

0.13%

Decreased

Fidelity Central Investment Portfolios LLC

200.0K

Weight

1.10%

No change

VANGUARD WORLD FUND

159.0K

Weight

0.05%

Increased

TRUST FOR PROFESSIONAL MANAGERS

151.6K

Weight

0.03%

Increased

Edgewise Therapeutics, Inc.· EWTX

Holdings Analysis

Insider Trading Activity

1.3Transaction History135Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings62Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights

Search stocks

Holdings Analysis

Insider Trading Activity

1.3Transaction History135Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings62Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights