Alnylam Pharmaceuticals, Inc.· ALNY

🇺🇸 US · LargeBroad USNASDAQ

Healthcare Biotechnology Website

Price: $239.56
Day: -2.42%
Mkt Cap: $32.06B
52W Range: $197.81 – $495.55
Volume: 2.76M
Beta: 0.30

D55D FrameworkQuarterly Data

Holdings Analysis

Insider activity, institutional flows, and fund ownership.

Smart Money: 3.8 / 5 (Bullish), from 3 of 3 components
Institutions Q2 2026: 829 institutions hold; 411 added, 288 reduced

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Alnylam Pharmaceuticals, Inc.

ALNY|Healthcare|Biotechnology

Current price: $240

Smart Money

Dimension 5 of 5

Insider selling pace · Q2 2026

0.1x

vs own 6-quarter average

Seller breadth · Q2 2026

2 sellers

vs 5.0 avg per quarter

Institutional net breadth · Q2 2026

+123

500 adding vs 377 reducing

Institutional ownership · Q2 2026

N/A

overlapping 13F filings

Insider Selling Pace

Each quarter's selling vs this stock's own trailing 6-quarter average

Light <0.5xRoutineElevated >1.5xHeavy >3xBuying

Institutional Positions

Institutions adding above the line, reducing below, net as a line

NewIncreasedReducedClosedNet

Largest Institutional Holders, Q2 2026

By reported market value, and how each moved in the quarter

Holder

Change

FMR LLC

15.0M

+2.8%

CAPITAL WORLD INVESTORS

11.1M

+2.9%

BLACKROCK, INC.

10.9M

+4.2%

CAPITAL RESEARCH GLOBAL INVESTORS

9.8M

+2.7%

VANGUARD PORTFOLIO MANAGEMENT LLC

6.5M

+0.5%

VANGUARD CAPITAL MANAGEMENT LLC

6.0M

+1.1%

ETF & Fund Activity, Q2 2026

How the covering funds split between buying, holding and selling

139

112

139 buying139 unchanged112 selling

390 funds held ALNY in Q2 2026, holding 73.3M shares between them, down 0.7% on the quarter.

Largest fund holders

SPDR SERIES TRUST361.9K sh

NATIONWIDE MUTUAL FUNDS72.3K sh

Nuveen S&P 500 Dynamic Overwrite Fund4.5K sh

Notable Insider Transactions, Q2 2026

Largest open-market purchases and sales by value in the last eight quarters

Sale · May 30

Greenstreet Yvonne

$7.7M

Sale · Jun 2

Greenstreet Yvonne

$5.9M

Sale · Aug 18

BONNEY MICHAEL W

$5.1M

Insider transactions from SEC Form 4 filings; institutional holdings from quarterly 13F filings, which are reported with a lag and can overlap between filers. 13F: quarterly institutional holdings report · ETF: Exchange-Traded Fund

See the complete picture

The full 5D Framework: Business Quality · Peer Comparison · Valuation · Analyst Sentiment · Smart Money

Explore ALNY on stockoscope.com→

Generated September 22, 2026

For educational purposes only. Not financial advice. Data may be delayed or incomplete.

Smart Money Sentiment

ALNY Smart Money Sentiment Score

A weighted 1-5 sentiment score across three smart money signals.

Smart Money

3.8/5

Bullish

Weighted across 3 components

Component Breakdown (3 of 3 available)

Insider Activity

40% weight

+25

Institutional Flow

50% weight

+48

Fund Flow

10% weight

+25

Overall Smart Money sentiment of 3.8/5 (Bullish) based on a weighted combination of 3 components. Insider activity uses a relative-baseline comparison against the stock's own history; institutional flow tracks position momentum and 13F share changes; fund flow measures ETF / mutual-fund buying vs selling. Higher scores indicate stronger bullish sentiment from professional investors.Last updated September 21, 2026.

Insider Trading Activity

Insider trading analysis comparing the latest quarter against the stock's own historical baseline.

Insider Selling Pace for ALNY

Each quarter's selling vs the stock's own trailing 6-quarter average; 1.0x is typical for this stock. Green triangles mark quarters with insider buying.

Bullish Signal

Insider selling eased in Q2 2026

19 sales totaling $2.4M (7.7K shares)

Share volume is well below the historical pace (0.1x average), insiders are holding more

Buying seen in 2 of 15 quarters

Selling has increased for 4 straight quarters

0.1x

Selling pace

vs own 6-qtr average

Light

2.57%

Stake sold

of active insiders' holdings

2 sellers

Seller breadth

vs 5.0 avg per quarter

Q4 2024

Last insider purchase

buying in 2 of 16 quarters

Notable Recent Transactions, ALNY

Top 8 highest-value insider trades from the last 8 quarters

Greenstreet Yvonne

CEO

Sell

25,469 shares at $304.00

≈31.6% of their stake at the time

May 30, 2025$7.74M

Greenstreet Yvonne

CEO

Sell

19,297 shares at $306.00

≈28.3% of their stake at the time

Jun 2, 2025$5.90M

BONNEY MICHAEL W

Director

Sell

11,250 shares at $450.00

≈40.1% of their stake at the time

Aug 18, 2025$5.06M

Fitzgerald Kevin Joseph

Cso & EVP, Head of Research

Sell

8,168 shares at $449.00

≈24.5% of their stake at the time

Nov 17, 2025$3.67M

Ausiello Dennis A

Director

Sell

7,675 shares at $435.40

≈29.1% of their stake at the time

Aug 14, 2025$3.34M

Ausiello Dennis A

Director

Sell

5,358 shares at $436.00

≈28.7% of their stake at the time

Aug 14, 2025$2.34M

Ausiello Dennis A

Director

Sell

5,302 shares at $439.27

≈57.0% of their stake at the time

Aug 14, 2025$2.33M

PYOTT DAVID E I

Director

Sell

7,440 shares at $299.00

≈98.2% of their stake at the time

Mar 24, 2025$2.22M

Institutional Ownership Analysis

Institutional ownership analysis with position momentum, 13F share flow, and ownership percentage trends.

Institutional Positions for ALNY

Institutions adding (new + increased) above zero, reducing (reduced + closed) below, net as a line

New Increased Reduced Closed Net (adding − reducing)

Bullish Signal

Institutions accumulating in Q2 2026

13F filings cover more than 100% of shares this quarter (overlapping reports), so ownership and share-flow figures are unreliable

Slight accumulation: 500 adding vs 377 reducing

+123

Net breadth

500 adding vs 377 reducing

Accumulating

1.33

Add / reduce ratio

in Q2 2026

New − closed

89 initiated, 89 exited

9 of 10

Top holders adding

largest holders with a known change

Position Changes

Q2 2026: how are institutions adjusting their positions?

+500 growing-377 shrinkingNet: +123

411

288

New (89)

Increased (411)

Reduced (288)

Closed (89)

Top Institutional Holders, ALNY

Largest 8 institutional positions by ownership percentage as of Q2 2026

FMR LLC

15.0M

$4.5B

Ownership

11.28%

+2.8%

CAPITAL WORLD INVESTORS

11.1M

$3.4B

Ownership

8.36%

+2.9%

BLACKROCK, INC.

10.9M

$3.3B

Ownership

8.19%

+4.2%

CAPITAL RESEARCH GLOBAL INVESTORS

9.8M

$2.9B

Ownership

7.32%

+2.7%

VANGUARD PORTFOLIO MANAGEMENT LLC

6.5M

$2.0B

Ownership

4.91%

+0.5%

VANGUARD CAPITAL MANAGEMENT LLC

6.0M

$1.8B

Ownership

4.53%

+1.1%

T. ROWE PRICE INVESTMENT MANAGEMENT, INC.

5.6M

$1.7B

Ownership

4.23%

+8.4%

INVESCO LTD.

3.8M

$1.1B

Ownership

2.82%

+34.5%

ETF and Mutual Fund Holdings

ETF and mutual fund activity breakdown showing buying vs selling funds, top fund holders, and detailed holdings.

Fund Activity

Q2 2026: 390 ETFs and mutual funds reporting

139 buying112 sellingNet: +27

139

112

Buying (139)

Unchanged (139)

Selling (112)

In total, funds bought 5.3M shares and sold 5.8M this quarter. Each fund counts once in the bar above, whatever the size of its move.

Bullish Signal

Funds accumulating in Q2 2026

390 ETFs and mutual funds reporting

139 buying vs 112 selling (balanced)

Top Fund Holders, ALNY

Largest 8 ETF and mutual fund positions by shares held, each fund's latest filing

SPDR SERIES TRUST

361.9K

Weight

1.79%

Jul 31, 2026No change

NATIONWIDE MUTUAL FUNDS

72.3K

Weight

0.01%

Jul 31, 2026Increased

Nuveen S&P 500 Dynamic Overwrite Fund

4.5K

Weight

0.53%

Jun 30, 2026Increased

SEASONS SERIES TRUST

4.2K

Weight

0.02%

Jun 30, 2026Decreased

ALGER PORTFOLIOS

4.2K

Weight

0.73%

Jun 30, 2026No change

MML Series Investment Fund II

4.1K

Weight

0.03%

Jun 30, 2026No change

AUGUSTAR VARIABLE INSURANCE PRODUCTS FUND INC

4.0K

Weight

0.02%

Jun 30, 2026Decreased

ProFunds

4.0K

Weight

0.03%

Jun 30, 2026Increased

Alnylam Pharmaceuticals, Inc.· ALNY

Holdings Analysis

Insider Trading Activity

1.3Transaction History500Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings166Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights

Search stocks

Holdings Analysis

Insider Trading Activity

1.3Transaction History500Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings166Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights