Madrigal Pharmaceuticals, Inc.· MDGL

🇺🇸 US · LargeBroad USNASDAQ

Healthcare Biotechnology Website

Price: $531.52
Day: -0.54%
Mkt Cap: $12.28B
52W Range: $393.61 – $615.00
Volume: 330.6K
Beta: -0.99

D55D FrameworkQuarterly Data

Holdings Analysis

Insider activity, institutional flows, and fund ownership.

Smart Money: 3.4 / 5 (Neutral), from 3 of 3 components
Institutions Q2 2026: 439 institutions hold; 223 added, 136 reduced
Insiders Q3 2026: no purchases, 35 sales ($7.9M)

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Madrigal Pharmaceuticals, Inc.

MDGL|Healthcare|Biotechnology

Current price: $532

Smart Money

Dimension 5 of 5

Insider selling pace · Q3 2026

0.2x

quarter in progress, filings still arriving

Seller breadth · Q3 2026

2 sellers

vs 5.8 avg per quarter

Institutional net breadth · Q2 2026

+122

302 adding vs 180 reducing

Institutional ownership · Q2 2026

81.6%

439 institutions

Insider Selling Pace

Each quarter's selling vs this stock's own trailing 6-quarter average

Light <0.5xRoutineElevated >1.5xHeavy >3xBuying

Institutional Positions

Institutions adding above the line, reducing below, net as a line

NewIncreasedReducedClosedNet

Largest Institutional Holders, Q2 2026

By reported market value, and how each moved in the quarter

Holder

Change

BAKER BROS. ADVISORS LP

2.1M

-0.3%

RTW INVESTMENTS, LP

2.0M

-0.4%

JUPITER TOPCO LLC

1.9M

+100.0%

AVORO CAPITAL ADVISORS LLC

1.8M

+0.4%

PAULSON & CO. INC.

1.3M

-4.1%

BLACKROCK, INC.

1.2M

-23.3%

ETF & Fund Activity, Q2 2026

How the covering funds split between buying, holding and selling

106

73 buying106 unchanged94 selling

273 funds held MDGL in Q2 2026, holding 8.3M shares between them, down 4.6% on the quarter.

Largest fund holders

SPDR SERIES TRUST211.3K sh

ALGER PORTFOLIOS5.2K sh

COLUMBIA FUNDS VARIABLE INSURANCE TRUST5.2K sh

Notable Insider Transactions, Q3 2026

Largest open-market purchases and sales by value in the last eight quarters

Sale · Aug 13

FRIEDMAN PAUL A

$10.8M

Purchase · Aug 18

BAKER BROS. ADVISORS LP

$10.0M

Sale · Aug 13

FRIEDMAN PAUL A

$9.0M

Insider transactions from SEC Form 4 filings; institutional holdings from quarterly 13F filings, which are reported with a lag and can overlap between filers. 13F: quarterly institutional holdings report · ETF: Exchange-Traded Fund

See the complete picture

The full 5D Framework: Business Quality · Peer Comparison · Valuation · Analyst Sentiment · Smart Money

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Generated September 20, 2026

For educational purposes only. Not financial advice. Data may be delayed or incomplete.

Smart Money Sentiment

MDGL Smart Money Sentiment Score

A weighted 1-5 sentiment score across three smart money signals.

Smart Money

3.4/5

Neutral

Weighted across 3 components

Component Breakdown (3 of 3 available)

Insider Activity

40% weight

Institutional Flow

50% weight

+42

Fund Flow

10% weight

-25

Overall Smart Money sentiment of 3.4/5 (Neutral) based on a weighted combination of 3 components. Insider activity uses a relative-baseline comparison against the stock's own history; institutional flow tracks position momentum and 13F share changes; fund flow measures ETF / mutual-fund buying vs selling. Higher scores indicate stronger bullish sentiment from professional investors.Last updated September 19, 2026.

Insider Trading Activity

Insider trading analysis comparing the latest quarter against the stock's own historical baseline.

Insider Selling Pace for MDGL

Each quarter's selling vs the stock's own trailing 6-quarter average; 1.0x is typical for this stock. Green triangles mark quarters with insider buying.

Neutral

Routine insider selling in Q3 2026

35 sales totaling $7.9M (14.7K shares)

Share volume is well below the historical pace (0.2x average), insiders are holding more

Buying seen in 3 of 15 quarters

Net insider flow has deteriorated over recent quarters

0.2x

Selling pace

quarter in progress, filings still arriving

0.21%

Stake sold

of active insiders' holdings

2 sellers

Seller breadth

vs 4.8 avg per quarter

Q3 2025

Last insider purchase

buying in 3 of 16 quarters

Notable Recent Transactions, MDGL

Top 8 highest-value insider trades from the last 8 quarters

FRIEDMAN PAUL A

Director

Sell

28,976 shares at $372.39

≈11.9% of their stake at the time

Aug 13, 2025$10.79M

BAKER BROS. ADVISORS LP

Director

Buy

26,704 shares at $372.87

≈1.4% of their stake after buying

Aug 18, 2025$9.96M

FRIEDMAN PAUL A

Director

Sell

24,166 shares at $373.35

≈11.2% of their stake at the time

Aug 13, 2025$9.02M

FRIEDMAN PAUL A

Director

Sell

22,710 shares at $371.53

≈8.5% of their stake at the time

Aug 13, 2025$8.44M

BAKER BROS. ADVISORS LP

Director

Buy

13,545 shares at $385.06

≈0.7% of their stake after buying

Aug 20, 2025$5.22M

Daly James M

Director

Sell

14,302 shares at $347.39

≈84.2% of their stake at the time

Feb 27, 2025$4.97M

FRIEDMAN PAUL A

Director

Sell

7,193 shares at $551.67

≈3.5% of their stake at the time

Dec 10, 2025$3.97M

BAKER BROS. ADVISORS LP

Director

Buy

10,128 shares at $372.16

≈0.5% of their stake after buying

Aug 18, 2025$3.77M

Institutional Ownership Analysis

Institutional ownership analysis with position momentum, 13F share flow, and ownership percentage trends.

Institutional Positions for MDGL

Institutions adding (new + increased) above zero, reducing (reduced + closed) below, net as a line

New Increased Reduced Closed Net (adding − reducing)

Bullish Signal

Institutions accumulating in Q2 2026

81.6% institutional ownership

Moderate accumulation: 302 adding vs 180 reducing

13F share count essentially flat

Momentum improving from prior quarter

+122

Net breadth

302 adding vs 180 reducing

Accumulating

1.68

Add / reduce ratio

in Q2 2026

+35

New − closed

79 initiated, 44 exited

4 of 10

Top holders adding

largest holders with a known change

Position Changes

Q2 2026: how are institutions adjusting their positions?

+302 growing-180 shrinkingNet: +122

223

136

New (79)

Increased (223)

Reduced (136)

Closed (44)

Top Institutional Holders, MDGL

Largest 8 institutional positions by ownership percentage as of Q2 2026

BAKER BROS. ADVISORS LP

2.1M

$1.2B

Ownership

7.35%

-0.3%

RTW INVESTMENTS, LP

2.0M

$1.1B

Ownership

6.84%

-0.4%

JUPITER TOPCO LLC

1.9M

$1.0B

Ownership

6.64%

+100.0%

AVORO CAPITAL ADVISORS LLC

1.8M

$984.4M

Ownership

6.29%

+0.4%

PAULSON & CO. INC.

1.3M

$719.5M

Ownership

4.60%

-4.1%

BLACKROCK, INC.

1.2M

$644.8M

Ownership

4.12%

-23.3%

VANGUARD CAPITAL MANAGEMENT LLC

835.7K

$448.7M

Ownership

2.87%

+0.6%

WELLINGTON MANAGEMENT GROUP LLP

825.7K

$443.4M

Ownership

2.83%

+18.4%

ETF and Mutual Fund Holdings

ETF and mutual fund activity breakdown showing buying vs selling funds, top fund holders, and detailed holdings.

Fund Activity

Q2 2026: 273 ETFs and mutual funds reporting

73 buying94 sellingNet: -21

106

Buying (73)

Unchanged (106)

Selling (94)

In total, funds bought 400.3K shares and sold 784.8K this quarter. Each fund counts once in the bar above, whatever the size of its move.

Bearish Signal

Funds distributing in Q2 2026

273 ETFs and mutual funds reporting

94 funds selling vs 73 buying

Top Fund Holders, MDGL

Largest 8 ETF and mutual fund positions by shares held, each fund's latest filing

SPDR SERIES TRUST

211.3K

Weight

1.04%

Jul 31, 2026No change

ALGER PORTFOLIOS

5.2K

Weight

0.90%

Jun 30, 2026No change

COLUMBIA FUNDS VARIABLE INSURANCE TRUST

5.2K

Weight

0.01%

Jun 30, 2026Increased

ADVANCED SERIES TRUST

4.7K

Weight

0.00%

Jun 30, 2026Decreased

OPTIMUM FUND TRUST

4.6K

Weight

0.01%

Jun 30, 2026No change

MASSMUTUAL SELECT FUNDS

4.5K

Weight

0.25%

Jun 30, 2026Increased

BARON SELECT FUNDS

4.5K

Weight

0.07%

Jun 30, 2026Decreased

VANGUARD HORIZON FUNDS

3.6K

Weight

0.01%

Jun 30, 2026No change

Madrigal Pharmaceuticals, Inc.· MDGL

Holdings Analysis

Insider Trading Activity

1.3Transaction History500Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings142Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights

Search stocks

Holdings Analysis

Insider Trading Activity

1.3Transaction History500Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings142Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights