Praxis Precision Medicines, Inc.· PRAX

🇺🇸 US · MidBroad USNASDAQ

Healthcare Biotechnology Website

Price: $298.95
Day: -3.71%
Mkt Cap: $8.33B
52W Range: $41.78 – $392.70
Volume: 829.9K
Beta: 2.78

D55D FrameworkQuarterly Data

Holdings Analysis

Insider activity, institutional flows, and fund ownership.

Smart Money: 3.6 / 5 (Bullish), from 3 of 3 components
Institutions Q2 2026: 330 institutions hold; 183 added, 98 reduced

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Praxis Precision Medicines, Inc.

PRAX|Healthcare|Biotechnology

Current price: $299

Smart Money

Dimension 5 of 5

Insider selling pace · Q2 2026

N/A

insufficient history to compare

Seller breadth · Q2 2026

1 seller

vs 2.0 avg per quarter

Institutional net breadth · Q2 2026

+101

243 adding vs 142 reducing

Institutional ownership · Q2 2026

N/A

overlapping 13F filings

Insider Selling Pace

Each quarter's selling vs this stock's own trailing 6-quarter average

Light <0.5xRoutineElevated >1.5xHeavy >3xBuying

Institutional Positions

Institutions adding above the line, reducing below, net as a line

NewIncreasedReducedClosedNet

Largest Institutional Holders, Q2 2026

By reported market value, and how each moved in the quarter

Holder

Change

JUPITER TOPCO LLC

3.4M

+100.0%

FMR LLC

2.3M

+6.3%

BLACKROCK, INC.

2.3M

-2.2%

PERCEPTIVE ADVISORS LLC

2.0M

-0.9%

BAKER BROS. ADVISORS LP

1.8M

-0.9%

ORBIS ALLAN GRAY LTD

1.5M

-38.7%

ETF & Fund Activity, Q2 2026

How the covering funds split between buying, holding and selling

130

113

130 buying113 unchanged52 selling

222 funds held PRAX in Q2 2026, holding 26.2M shares between them, up 6.1% on the quarter.

Largest fund holders

SPDR SERIES TRUST413.7K sh

Fidelity Central Investment Portfolios LLC43.5K sh

J.P. Morgan Exchange-Traded Fund Trust10.9K sh

Notable Insider Transactions, Q2 2026

Largest open-market purchases and sales by value in the last eight quarters

Sale · Nov 20

Nemiroff Alex

$2.6M

Sale · Nov 20

Mastrocola Lauren

$2.2M

Sale · Nov 20

Nemiroff Alex

$1.8M

Insider transactions from SEC Form 4 filings; institutional holdings from quarterly 13F filings, which are reported with a lag and can overlap between filers. 13F: quarterly institutional holdings report · ETF: Exchange-Traded Fund

See the complete picture

The full 5D Framework: Business Quality · Peer Comparison · Valuation · Analyst Sentiment · Smart Money

Explore PRAX on stockoscope.com→

Generated September 21, 2026

For educational purposes only. Not financial advice. Data may be delayed or incomplete.

Smart Money Sentiment

PRAX Smart Money Sentiment Score

A weighted 1-5 sentiment score across three smart money signals.

Smart Money

3.6/5

Bullish

Weighted across 3 components

Component Breakdown (3 of 3 available)

Insider Activity

40% weight

-30

Institutional Flow

50% weight

+70

Fund Flow

10% weight

+60

Overall Smart Money sentiment of 3.6/5 (Bullish) based on a weighted combination of 3 components. Insider activity uses a relative-baseline comparison against the stock's own history; institutional flow tracks position momentum and 13F share changes; fund flow measures ETF / mutual-fund buying vs selling. Higher scores indicate stronger bullish sentiment from professional investors.Last updated September 20, 2026.

Insider Trading Activity

Insider trading analysis comparing the latest quarter against the stock's own historical baseline.

Insider Selling Pace for PRAX

Each quarter's selling vs the stock's own trailing 6-quarter average; 1.0x is typical for this stock. Green triangles mark quarters with insider buying.

Bearish Signal

Elevated insider selling in Q2 2026

12 sales totaling $3.6M (11.6K shares)

Limited history to compare against

All sales came from a single insider

Buying seen in 3 of 15 quarters

N/A

Selling pace

insufficient history to compare

0.36%

Stake sold

of active insiders' holdings

1 seller

Seller breadth

all sales from one insider

Q4 2023

Last insider purchase

buying in 3 of 16 quarters

Notable Recent Transactions, PRAX

Top 8 highest-value insider trades from the last 8 quarters

Nemiroff Alex

General Counsel

Sell

13,339 shares at $192.53

≈30.1% of their stake at the time

Nov 20, 2025$2.57M

Mastrocola Lauren

Chief Accounting Officer

Sell

11,455 shares at $191.96

≈47.6% of their stake at the time

Nov 20, 2025$2.20M

Nemiroff Alex

General Counsel

Sell

9,100 shares at $194.30

≈30.4% of their stake at the time

Nov 20, 2025$1.77M

DeSimone Jill

Director

Sell

2,854 shares at $311.91

≈32.4% of their stake at the time

Jun 24, 2026$890.20K

Nemiroff Alex

General Counsel

Sell

8,239.33 shares at $80.20

≈44.4% of their stake at the time

Nov 14, 2024$660.83K

DeSimone Jill

Director

Sell

1,750 shares at $310.89

≈16.6% of their stake at the time

Jun 24, 2026$544.06K

Mastrocola Lauren

Chief Accounting Officer

Sell

5,188.34 shares at $81.78

≈48.0% of their stake at the time

Nov 14, 2024$424.32K

Mastrocola Lauren

Chief Accounting Officer

Sell

2,145 shares at $192.71

≈17.0% of their stake at the time

Nov 20, 2025$413.37K

Institutional Ownership Analysis

Institutional ownership analysis with position momentum, 13F share flow, and ownership percentage trends.

Institutional Positions for PRAX

Institutions adding (new + increased) above zero, reducing (reduced + closed) below, net as a line

New Increased Reduced Closed Net (adding − reducing)

Very Bullish

Institutions accumulating in Q2 2026

13F filings cover more than 100% of shares this quarter (overlapping reports), so ownership and share-flow figures are unreliable

Moderate accumulation: 243 adding vs 142 reducing

Momentum weakening from prior quarter

+101

Net breadth

243 adding vs 142 reducing

Accumulating

1.71

Add / reduce ratio

in Q2 2026

+16

New − closed

60 initiated, 44 exited

6 of 10

Top holders adding

largest holders with a known change

Position Changes

Q2 2026: how are institutions adjusting their positions?

+243 growing-142 shrinkingNet: +101

183

New (60)

Increased (183)

Reduced (98)

Closed (44)

Top Institutional Holders, PRAX

Largest 8 institutional positions by ownership percentage as of Q2 2026

JUPITER TOPCO LLC

3.4M

$1.1B

Ownership

11.74%

+100.0%

FMR LLC

2.3M

$775.7M

Ownership

7.95%

+6.3%

BLACKROCK, INC.

2.3M

$767.5M

Ownership

7.87%

-2.2%

PERCEPTIVE ADVISORS LLC

2.0M

$681.6M

Ownership

6.99%

-0.9%

BAKER BROS. ADVISORS LP

1.8M

$587.0M

Ownership

6.02%

-0.9%

ORBIS ALLAN GRAY LTD

1.5M

$512.2M

Ownership

5.25%

-38.7%

VANGUARD PORTFOLIO MANAGEMENT LLC

1.3M

$447.0M

Ownership

4.58%

+74.9%

VANGUARD CAPITAL MANAGEMENT LLC

1.2M

$413.6M

Ownership

4.24%

+0.2%

ETF and Mutual Fund Holdings

ETF and mutual fund activity breakdown showing buying vs selling funds, top fund holders, and detailed holdings.

Fund Activity

Q2 2026: 295 ETFs and mutual funds reporting

130 buying52 sellingNet: +78

130

113

Buying (130)

Unchanged (113)

Selling (52)

In total, funds bought 2.0M shares and sold 365.4K this quarter. Each fund counts once in the bar above, whatever the size of its move.

Very Bullish

Funds accumulating in Q2 2026

295 ETFs and mutual funds reporting

130 funds buying vs 52 selling

Top Fund Holders, PRAX

Largest 8 ETF and mutual fund positions by shares held, each fund's latest filing

SPDR SERIES TRUST

413.7K

Weight

2.05%

Jul 31, 2026No change

Fidelity Central Investment Portfolios LLC

43.5K

Weight

0.08%

Jun 30, 2026Increased

J.P. Morgan Exchange-Traded Fund Trust

10.9K

Weight

0.00%

Jun 30, 2026No change

JPMorgan Trust I

9.6K

Weight

0.00%

Jun 30, 2026Decreased

VARIABLE INSURANCE PRODUCTS FUND

9.5K

Weight

0.05%

Jun 30, 2026Increased

NEUBERGER BERMAN ADVISERS MANAGEMENT TRUST

8.8K

Weight

0.66%

Jun 30, 2026Increased

T. Rowe Price Equity Series, Inc.

8.6K

Weight

0.52%

Jun 30, 2026Decreased

OPTIMUM FUND TRUST

8.4K

Weight

0.01%

Jun 30, 2026Increased

Praxis Precision Medicines, Inc.· PRAX

Holdings Analysis

Insider Trading Activity

1.3Transaction History46Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings126Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights

Search stocks

Holdings Analysis

Insider Trading Activity

1.3Transaction History46Real market purchases and sales onlyShow All Types

Institutional Ownership Analysis

2.4Detailed Holdings126Most recent institutional positions with changes and valuations

ETF and Mutual Fund Holdings

3.3Fund Holdings Details25Most recent ETF and mutual fund holdings with share counts and weights